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The effect of zinc sulfate on immunologic response to recombinant hepatitis B vaccine in elderly

AUTHORS

Mandana Afsharian 1 , Siavash Vaziri 1 , Ali Reza Janbakhsh 1 , Babak Sayad 1 , Feizollah Mansouri 2 , * , Javad Nourbakhsh 1 , Keyghobad Qadiri 1 , Farid Najafi 1 , Maria Shirvanii 1

AUTHORS INFORMATION

1 Kermanshah Liver Disease and Hepatitis Research Center, Kermanshah University of Medical Sciences, IR Iran

2 Kermanshah Liver Disease and Hepatitis Research Center, Kermanshah University of Medical Sciences, fmansoury@yahoo.com, IR Iran

How to Cite: Afsharian M, Vaziri S, Janbakhsh A, Sayad B, Mansouri F, et al. The effect of zinc sulfate on immunologic response to recombinant hepatitis B vaccine in elderly, Hepat Mon. Online ahead of Print ; 11(1):32-35.

ARTICLE INFORMATION

Hepatitis Monthly: 11 (1); 32-35
Article Type: Research Article
Received: July 27, 2010
Accepted: September 7, 2010

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Abstract

Background: Hepatitis B is the major cause of chronic hepatitis and cirrhosis in Iran. Sanitation and immunization is one of the most effective measures for prevention of the disease which is now widely used in developing countries. However, the immune response to the vaccine varies by age.
Objectives: To determine the effect of zinc sulfate on immune response to hepatitis-B vaccine in elderly.
Patients and Methods: In a clinical trial on 140 subjects aged ≥40 years with a body mass index (BMI) <30 kg/m2, and without any co-morbid disease were recruited. Those who had negative hepatitis B core antibody (102 persons) were randomly allocated to two groups. The trial group received hepatitis B vaccine plus 200 mg zinc sulfate daily for 30 days and the control group received vaccine plus placebo.
Results: 52 of 102 people were female (51%). The two studied groups were comparable in terms of age, gender, and smoking habits. The mean antibody production in the intervention and control groups was 116.93 and 157.37 mIU/mL, respectively (p=0.22). No statistical differences were observed between the two groups in terms of proportion of people who were protected after vaccination (26.0% and 36.5% in people with and without zinc, respectively).
Conclusions: This study revealed that zinc sulfate has no effect in level of immunity among elderly.

  • Implication for Health policy/practice/research/medical education:
    This article shows the effect of adding trace elements in response to routine vaccination program against hepatitis B virus. Reading this article is recommended especially for the personnel involved as primary health car workers.
  • Please cite this paper as:
    Afsharian M, Vaziri S, Janbakhsh AR, Sayad B, Mansouri F, Nourbakhsh J, et al. The effect of zinc sulfate on immunologic response to recombinant hepatitis B vaccine in elderly. Hepat Mon. 2011;11(1):32-35.

2011 Kowsar M.P.Co. All rights reserved.

Keywords

Hepatitis B Vaccination Zinc sulfate Immunity

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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