Non-alcoholic steatohepatitis: An update in pathophysiology, diagnosis and therapy
Hossein Khedmat
1
, *
and
Saeed Taheri
2
1 Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Khedmat.h@gmail.com, IR.Iran
2 Dr. Taheri Medical Research Group, IR.Iran
*
Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Khedmat.h@gmail.com, IR.Iran. Tel: +98-2188964763. Fax: +98-2181262072. Email:
Khedmat.h@gmail.com
Hepatitis Monthly: ,
11 (2) ; 74-85 Article Type: Review Article
Received:
May 23, 2010
Accepted:
August 27, 2010
To Cite:
Khedmat
H, Taheri
S. Non-alcoholic steatohepatitis: An update in pathophysiology, diagnosis and therapy,
Hepat Mon.
Online ahead of Print
;11(2):74-85.
Abstract
Non-alcoholic steatohepatitis (NASH), first described by Ludwig et al, in 1980, is a stage in the wide spectrum of non-alcoholic fatty liver diseases (NAFLDs) and one of the leading causes of chronic liver disease. Several scientists have tried to more distinctly discover and describe different aspects of NASH. In contrast with its counterpart in the NAFLDs-the NAFL-NASH consists of inflammation as well as necrosis in the liver tissue resulting in a poor outcome. NASH is also a known etiology for cryptogenic liver cirrhosis. Evidence suggests that cirrhosis developing due to NASH have a relatively worse outcome compared to that of hepatitis C-related cirrhosis. In this review article, we try to review and present all relevant articles about NASH.
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