IF: 1.578
Cite Score:
1.45
THOMSON REUTERS - SCOPUS

Cytogenetic methods for detection of oxidative stress and evaluation of antioxidant therapy in hepatitis C infection

AUTHORS

Ingrid Emerit 1 , *

AUTHORS INFORMATION

1 Paris VI University and National Center of Scientific Research, ingrid.emerit@wanadoo.fr, France

How to Cite: Emerit I. Cytogenetic methods for detection of oxidative stress and evaluation of antioxidant therapy in hepatitis C infection, Hepat Mon. Online ahead of Print ; 11(6):434-439.

ARTICLE INFORMATION

Hepatitis Monthly: 11 (6); 434-439
Article Type: Review Article
Received: January 4, 2011
Accepted: April 1, 2011

Crossmark

CHEKING

READ FULL TEXT
Abstract

The plasma of patients with hepatitis C contains chromosome-damaging substances, the so-called "clastogenic factors" (CFs), as this is the case for other chronic inflammatory diseases and after radiation exposure. These endogenous clastogens, formed as a consequence of increased superoxide production by inflammatory cells, can be detected with cytogenetic methods, as they are used for exogenous clastogens. The long-lived, autosustained DNA-damaging effects of CFs are risk factors for the development of cancer and leukemia. In hepatitis C, the highest clastogenic scores has been observed in patients with hepatocellular carcinoma. In agreement with the link to inflammation, clastogenic score are correlated with necro-inflammatory scores in liver biopsies. Antioxidant therapy with a powerful superoxide scavenger resulted in normalization of clastogenic scores and significant decreases in aminotransferase levels, but did not influence the virus load. Preliminary results of our study on a limited number of patients suggest that pre-treatment with antioxidants may improve the outcome of interferon/ribavirin treatment. A comparison of a three-month treatment with either interferon alone or the antioxidant alone, yielded similar results for reduction of ALT levels, but only complete normalization of clastogenic scores for the antioxidant. Further studies have to be conducted to see whether a combination of an antiviral agent with an appropriate antioxidant would allow to reduce interferon and its side effects.Combination of antioxidants with IFN/RIBA was also reported by other authors with discordant results. The CF-test can be useful in clinical trials for the choice of the appropriate antioxidant.

 


  • Implication for health policy/practice/research/medical education:
    The fact that DNA damage induced during chronic hepatitis C may be reduced by antioxidants is of importance for prevention of hepatocellular carcinomas. The CF-test is an appropriate and easy tool to follow chromosome mutation in the disease process.
  • Please cite this paper as:
    Emerit I. Cytogenetic methods for detection of oxidative stress and evaluation of antioxidant therapy in hepatitis C infection. Hepat Mon. 2011;11(6):434-39.

2011 Kowsar M.P.Co. All rights reserved.


Keywords

Hepatitis C virus Oxidative stress Cytogenetic

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Full Text

Full text is available in PDF

COMMENTS

LEAVE A COMMENT HERE: