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Association of Hepatitis C Virus With Insulin Resistance: Evidences From Animal Studies and Clinical Studie

AUTHORS

Sadaf Badar 1 , Sadaf Badar 1 , Bushra Khubaib 1 , Bushra Khubaib 1 , Muhammad Idrees 2 , * , Muhammad Idrees 1 , * , Abrar Hussain 1 , Abrar Hussain 1 , Zunaira Awan 1 , Zunaira Awan 1 , Sadia Butt 1 , Sadia Butt 1 , Samia Afzal 1 , Samia Afzal 1 , Madeeha Akram 1 , Madeeha Akram 1 , Zareen Fatima 1 , Zareen Fatima 1 , Mahwish Aftab 1 , Mahwish Aftab 1 , Sana Saleem 1 , Sana Saleem 1 , Sara Munir 1 , Sara Munir 1 , Bisma Rauff 1 , Bisma Rauff 1 , Mahrukh Naudhani 1 , Mahrukh Naudhani 1 , Ali Liaquat 1 , Liaquat Ali 1 , Muhammaad Ali 1 , Muhammaad Ali 1 , Irshad-ul Rehman 1 , Irshadul Rehman 1

AUTHORS INFORMATION

1 National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan

2 National Centre of Excellence in Molecular Biology, University of the Punjab, idreeskhan96@yahoo.com, Pakistan

Corresponding Authors:

How to Cite: Badar S, Badar S, Khubaib B, Khubaib B, Idrees M, et al. Association of Hepatitis C Virus With Insulin Resistance: Evidences From Animal Studies and Clinical Studie, Hepat Mon. Online ahead of Print ; 12(1):11-15. doi: 10.5812/kowsar.1735143X.807.

ARTICLE INFORMATION

Hepatitis Monthly: 12 (1); 11-15
Published Online: December 31, 2011
Article Type: Review Article
Received: January 11, 2011
Accepted: December 27, 2011
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Abstract

Context: HCV infection is strongly associated with development of insulin resistance and type-2 diabetes, however molecular mechanism of these associations is not known. The aim of this review was to conduct a comprehensive literature search to understand the nature of the association between hepatitis C virus (HCV) infection and insulin resistance (IR). We also explored the role of HCV core protein and NS5a in modulating the course of the insulin-signaling pathway.

Evidence Acquisitions: We searched Directory of Open Access Journals (DOAJ) Google Scholar, Pubmed (NLM), LISTA (EBSCO), Web of Science (TS and PakMediNet).

Results: Emerging evidence suggests an association between HCV infection and carotid/coronary vascular disease. IR appears to be a dominant underlying cause of accelerated atherosclerosis in patients with chronic hepatitis C (CHC). HCV can induce IR directly through the stimulation of SOCS3 and PPA2, and both of these molecules have been shown to inhibit interferon-? signaling. Improvement of insulin sensitivity may increase the response rate to antiviral treatment and prevent IR complications, including vascular diseases. The results of several clinical trials that have used insulin sensitizers (metformin and PPAR-? agonists) have been inconclusive.

Conclusions: Beside the association between HCV and IR, the published data also have showed the possible association of HCV core and NS5A protein with IR.

Keywords

Insulin Resistance NS5a Protein Hepatitis C

© 2011, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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