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The Effect of GBV-C Infection on CD4 Count and Viral Loads in Patients Infected With HIV

AUTHORS

Hossein Keyvani 1 , Hossein Keyvani 1 , Avid Mohammadi 1 , Avid Mohammadi 2 , Masoud Sabouri Ghannad 2 , * , Masoud Sabouri Ghannad 3 , * , Mahboobeh Hajabdolbaghi 1 , Mahboobeh Hajabdolbaghi 4

AUTHORS INFORMATION

1 School of Medicine, Tehran University of Medical Sciences, Tehran, IR Iran

2 Keyvan Virology Laboratory, Tehran, IR Iran

3 Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran

4 AIDS Research Center, Tehran University of Medical Sciences, Tehran, IR Iran

Corresponding Authors:

How to Cite: Keyvani H, Keyvani H, Mohammadi A, Mohammadi A, Sabouri Ghannad M, et al. The Effect of GBV-C Infection on CD4 Count and Viral Loads in Patients Infected With HIV, Hepat Mon. Online ahead of Print ; 12(1):39-42. doi: 10.5812/kowsar.1735143X.817.

ARTICLE INFORMATION

Hepatitis Monthly: 12 (1); 39-42
Published Online: December 31, 2011
Article Type: Research Article
Received: July 12, 2011
Accepted: January 7, 2012
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Abstract

Background: The picture that has emerged from studies investigating HIV infected people with GBV-C viremia is that they have lower plasma HIV viral loads in comparison with HIV-positive people who did not have the GBV-C viremia.

Objectives: Since GBV-C HIV coinfection has not been studied in Iran, we have designed a survey to study the outcomes of GBV-C infection on HIV infected individuals.

Patients and Methods: We analyzed 78 serum samples from HIV-positive patients in Tehran. The HIV positive statue was confirmed by Western blot in our laboratory. Next we detected GBV-C RNA by RT nested-PCR and divided our patient into GBV-C positive and GBV-C negative groups. The final step was measuring the CD4 count and HIV viral load and comparing the means of the CD4 count and HIV viral load in HIV-infected individuals in the GBV-C positive and GBV-C negative groups.

Results: We detected GBV-C RNA in 15 patients out of 78. The mean CD4 count was 607.13 compared to 415.87 in the GBV-C negative group and the difference was significant (P = 0.005). In contrast to the CD4 count there was no significant difference in HIV viral loads between HIV infected individuals in the GBV-C positive and GBV-C negative groups.

Conclusion: Although there was no significant difference in the mean of the HIV viral load between the GBV-C positive and GBV-C negative groups, the significantly higher CD4 mean in the GBV-C positive group compared with the GBV-C negative group suggests a beneficial effect of this coinfection.

Keywords

GB Virus C HIV Infection CD4 Lymphocyte Count

© 2011, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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