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Heme Oxygenase-1 mRNA Expression in Egyptian Patients With Chronic Liver Disease

AUTHORS

Sahar Saad El-Din Bessa 1 , * , Ehab Mostafa Mohamed Ali 2 , Abeer El-Sayed Abd El-Wahab 3 , Sherif Abd El-Monem Nor El-Din 2

AUTHORS INFORMATION

1 Department of Internal Medicine, Faculty of Medicine, Tanta University, saharbessa@yahoo.com, Egypt

2 Departments of Chemistry, Division of Biochemistry, Faculty of Science, Tanta University, Egypt

3 Department of Medical Biotechnology, Genetic Engineering and Biotechnology Research Institute, The Scientific Researchs City and Technology Applications, Egypt

ARTICLE INFORMATION

Hepatitis Monthly: 12 (4); 278-285
Article Type: Research Article
Received: August 7, 2011
Accepted: February 4, 2012
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Abstract

Background: Chronic liver disease (CLD) is a global medical problem. This disease is associated with increased hepatic oxidative stress. One of the antioxidant enzymes that protect cells against this stress is heme oxygenase-1 (HO-1).
Objectives: This study aimed to investigate the mRNA expression of HO-1 in Egyptian patients with CLD and its relation to oxidative stress biomarkers.
Patients and Methods: Levels of serum ferritin, carboxyhemoglobin, malondialdehyde (MDA), and erythrocyte-reduced glutathione (GSH) were measured, and HO-1 mRNA expression was detected in 45 CLD patients (15 with nonalcoholic steatohepatitis [NASH], 15 with chronic hepatitis C, and 15 with liver cirrhosis) and 15 healthy controls.
Results: HO-1 mRNA expression was increased in patients with NASH, chronic hepatitis C, and liver cirrhosis compared to controls. The expression in cirrhotic patients was significantly higher than that in patients with NASH and chronic hepatitis C. Compared to controls, patients with NASH, chronic hepatitis C, and liver cirrhosis had higher levels of ferritin, carboxyhemoglobin, and MDA and lower levels of GSH. HO-1 mRNA expression was positively correlated with levels of carboxyhemoglobin, serum ferritin, and serum MDA and negatively correlated with levels of erythrocyte GSH in CLD patients.
Conclusions: HO-1 mRNA expression was significantly increased in CLD patients, and the increase reflected the severity of the disease. The significant relationship between the increased HO-1 expression and oxidative stress biomarkers in patients with CLD suggests that HO-1 may play an important role in protecting the liver from oxidative stress-dependent damage. Therefore, induction of HO-1 could be a novel therapeutic option for CLD.


  • Implication for health policy/practice/research/medical education:
    The significant relations between the increased HO-1 expression and oxidative stress biomarkers in patients with CLD suggest that HO-1 may play an important role to protect the liver from oxidative stress-dependent damage. Reading this article is recommended to all internists and hepatologists.
  • Please cite this paper as:
    Bessa SS, Mohamed Ali EM, Abd El-Wahab AE, Nor El-Din SA. Heme Oxygenase-1 mRNA Expression in Egyptian Patients With Chronic Liver Disease. Hepat Mon. 2012;12(4):278-85. DOI: 10.5812/hepatmon.846

Copyright © 2012 Kowsar Corp. All rights reserved.


Keywords

Gene Expression Heme Oxygenase-1 Hepatitis C Virus Liver Cirrhosis Non-alcoholic Fatty Liver Disease Oxidative Stress

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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