IF: 1.578
Cite Score:
1.45
THOMSON REUTERS - SCOPUS

The Reduced Predictive Value of Interleukin 28b Gene Polymorphisms in a Cohort of Patients With Thyroiditis Developed During Antiviral Therapy for Chronic Hepatitis C: A Preliminary Study

AUTHORS

Huy A Tran 1 , * , Tracey L Jones 2 , Elizabeth A Ianna 2 , Robert A Gibson 2 , Glenn E M Reeves 1

AUTHORS INFORMATION

1 Hunter Area Pathology Service, John Hunter Hospital, huy.tran@hnehealth.nsw.gov.au, New South Wales 2310, Australia

2 Hepatitis C Service, Gastroenterology Department, John Hunter Hospital, Australia

How to Cite: Tran H, Jones T, Ianna E, Gibson R, Reeves G. The Reduced Predictive Value of Interleukin 28b Gene Polymorphisms in a Cohort of Patients With Thyroiditis Developed During Antiviral Therapy for Chronic Hepatitis C: A Preliminary Study, Hepat Mon. Online ahead of Print ; 12(8):6036. doi: 10.5812/hepatmon.6036 .

ARTICLE INFORMATION

Hepatitis Monthly: 12 (8); 6036
Published Online: August 30, 2012
Article Type: Research Article
Received: May 1, 2012
Accepted: May 22, 2012
Crossmark

Crossmark

CHEKING

READ FULL TEXT
Abstract

Background: Single nucleotide polymorphism in the interleukin28B (IL28B) gene was recently shown to be associated with a significant increase in response to interferon-? and ribavirin treatment in patients with chronic hepatitis C. Similarly, thyroid disease (TD) occurring during treatment confer an improved sustained virologic response (SVR).

Objectives: To determine the role of IL28B genotypes in a cohort of hepatitis C patients who develop TD during treatment and its relationship to SVR.

Patients and Methods: IL28B gene profiles including rs12979860, rs12980275 and rs 8099917 and their genotypes were determined in a cohort of 23 hepatitis C patients who developed TD during treatment and their relationship to SVR.

Results: Out of 23 studies cases, 19 has one or more favorable genotypes, of which 15 (78.9%) achieved SVR. Eleven has all three unfavorable genotypes and yet achieved 72.7 % SVR. The presence of more than one favorable genotype only correctly predicts SVR vs. non- SVR in ~50 % of cases, i.e. by chance.

Conclusions: Despite the small number of subjects, the presence of one or more unfavorable IL28B genotype does not portend a poor SVR prognostic outcome. This suggests that TD in this clinical context may be a critical factor in the achievement of SVR, probably above that of the genetic predisposition.

Keywords

Polymorphism, Genetic Hepatitis C Thyroiditis

© 2012, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Full Text

Full text is available in PDF

COMMENTS

LEAVE A COMMENT HERE: