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Age-Specific Seroprevalence of Anti-Hepatitis A Antibody Among 1-30 Years Old Population of Savadkuh, Mazandaran, Iran With Literature Review


Mohammed Jafar Saffar 1 , * , Omid Abedian 2 , Abolghasem Ajami 2 , Farshideh Abedian 2 , Araz Mohammad Mirabi 2 , Ali-Reza Khalilian 2 , Hana Saffar 3


1 Pediatric Infectious Diseases Ward and Thalassemia Research Center, Bouali-Cina Hospital, University of Medical Sciences, Saffar@softhome.net, IR Iran

2 Pediatric Infectious Diseases Ward and Thalassemia Research Center, Bouali-Cina Hospital, University of Medical Sciences, IR Iran

3 Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, IR Iran


Hepatitis Monthly: 12 (5); 326-332
Article Type: Research Article
Received: December 24, 2012
Accepted: April 21, 2012




Background: To determine age-speci?c seroprevalence rates of hepatitis A virus (HAV) immunoglobulin G (IgG) antibody in Savadkuh district, Mazandaran province, north of Iran, as well as to compare the collected data with earlier seroprevalence studies in the region and Iran in order to draw a proper epidemiological pattern for HAV infection in the country.
Objectives: This study aimed to assess an age-speci?c HAV seroprevalence among 1- to 30-yearold people in Savadkuh, a less developed district of Mazandaran province, north of Iran.
Patients and Methods: The study participants were 984 subjects who aged from one to 30 years and were residents of rural and urban areas of Savadkuh. They were selected using cluster sampling method and divided into ?ve age groups: 1-2.9 (316 cases), 3-6.9 (254 cases), 7-10.9 (201 cases), 11-17.9 (115 cases), and 18-30 (98 cases). Anti-HAV antibody was measured by ELISA method. Seroprevalence rates among different age groups and their relationship to residency, educational levels of parents, water supply, and waste water disposal system was analyzed using chi-squared test.
Results: Overall seroprevalence rate was 19.20 % with no signi?cant difference between rural and urban residents. The seroprevalence rates increased signi?cantly with age: from 5.7 % in age group 1-2.9 year to 34.8 % in adolescents, and to 68.4 % among young adults (P < 0.0001); regardless of signi?cant differences in educational levels among parents of residents in two areas it did not affect seroprevalence rates. Findings of this study and reviewing other reports from the region and the country suggest an epidemiological shift towards lower rates of anti-HAV antibody seroprevalence.
Conclusions: It appears that anti-HAV antibody seroprevalence rate has been declining among Iranians and thereby more children would be susceptible to this infection. This would necessitate revising current strateg.

Implication for health policy/practice/research/medical education:
This Article presents an age-specific Seroprevalence rate of (HAV) (IgG Antibody)among people in such a less developed district of Iran; savadkuh and it declares getting some strategies in preventative measuring.
Please cite this paper as:
Saffar M.J, Abedian O, Ajami A, Abedian F, Mirabi AM, Khalilian AR, et al. Age-Specific Seroprevalence of Anti-Hepatitis Aantibody Among 1-30 Years-Old Population of Savadkuh, Mazandaran, Iran With Literature Review . Hepat Mon. 2012;12(5):326-32.DOI:10.5812/hepatmon.603

Copyright © 2012 Kowsar Corp. All rights reserved.


Hepatitis A Virus Antibodies Seroprevalence Iran

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