Relationship Between HBV Genotypes B, C and Follicular Helper T Cells in Patients with Chronic Hepatitis B and its Significance

AUTHORS

Gu Xibing 1 , * , Yang Xiaojuan 1 , Wang Juanhua 1 , Hua Zhong 1

1 Department of Hepatology, Wuxi Hospital for Infectious Diseases, China

How to Cite: Xibing G, Xiaojuan Y, Juanhua W, Zhong H. Relationship Between HBV Genotypes B, C and Follicular Helper T Cells in Patients with Chronic Hepatitis B and its Significance, Hepat Mon. 2013 ; 13(1):6221. doi: 10.5812/hepatmon.6221.

ARTICLE INFORMATION

Hepatitis Monthly: 13 (1); 6221
Published Online: January 20, 2013
Article Type: Research Article
Received: May 12, 2012
Accepted: October 21, 2012
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Abstract

Background: Clinical observations have shown that patients infected with chronic hepatitis B virus (HBV) genotype C versus genotype B had a higher load of the virus, more serious illness, and poorer responses to antiviral therapy and prognosis. However, the disparity between the two has not been clarified.

Objectives: To explore possible relationship between HBV genotypes B and C and peripheral blood follicular helper T cells (Tfh) and its significance in treating chronic hepatitis B (CHB) patients.

Patients and Methods: One hundred and fifty CHB patients were enrolled into this study, including 70 cases infected with HBV genotype C and 79 cases with genotype B. One patient had suffered from both genotypes B and C. The levels of Tfh, also known as interleukin-21 (IL-21), HBV specific cytotoxic T lymphocytes (CTL), HBV DNA and alanine transaminase (ALT) were evaluated and compared in patients infected with genotype B and C.

Results: Levels of Tfh, IL-21 and HBV specific CTL of patients infected with HBV genotype C were significantly lower than those of patients infected with HBV genotype B, P < 0.01. Levels of HBV DNA and ALT of patients infected with genotype C were significantly higher than those of the patients infected with HBV genotype B, P < 0.01.

Conclusions: Compared with chronic hepatitis B (CHB) patients infected with genotype B, higher levels of serum HBV DNA, ALT and TBil of patients infected with HBV genotype C may be related to their lower level of peripheral blood Tfh, which may result in lower IL-21, and it may result in lower HBV specific CTL.

Keywords

Hepatitis B Virus Genotype T-Lymphocytes, Helper-Inducer Receptors, Interleukin-21 T-Lymphocytes, Cytotoxic

© 2013, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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