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A Randomized Controlled Trial of Two Schedules of Hepatitis B Vaccination in Predialysed Chronic Renal Failure Patients

AUTHORS

Farokhlagha Ahmadi 1 , Morteza Ramezani 1 , Effat Razeghi 1 , Neda Ranjbarnovin 1 , Zahra Khazaeipour 2 , *

AUTHORS INFORMATION

1 Nephrology Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, IR Iran

2 1) Nephrology Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences. 2) Brain and Spinal Injury Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, z_kh14@yahoo.com, IR Iran

ARTICLE INFORMATION

Hepatitis Monthly: 12 (5); 344-348
Article Type: Research Article
Received: October 23, 2011
Accepted: March 28, 2012
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Abstract

Background: Patients with chronic renal disease should be vaccinated as soon as dialysis is forestalled, and this could improve the seroconversion of hepatitis B vaccination.
Objectives: In this study, we aimed to compare seroconversion and immune response rates using 4 doses of 40 μg and 3 doses of 20 μg Euvax B recombinant Hepatitis B surface Antigen (HBs Ag) vaccine administered to predialysis patients with chronic kidney disease (CKD).
Patients and Methods: In an open, randomized clinical trial, we compared seroconversion rates in 51 predialysis patients with mild and moderate chronic renal failure who received either 4 doses of 40 μg or 3 doses of 20 μg of Euvax B recombinant hepatitis B vaccine administered at 0, 1, 2, 6 and 0, 1, 6 months, respectively.
Results: Differences in seroconversion rates after 4 doses of 40 μg (80.88%) compared to 3 doses of 20 μg (92%) were not significant (P = 0.4124). The mean HBs antibody level after 4 doses of 40 μg at 0, 1, 2, and 6 months (182.2 ± 286.7) was significantly higher than that after 3 doses of 40 μg at 0,1, and 6 months (96.9 ± 192.1) (P = 0.004). Seroconversion after 4 doses of 40 μg (80.8%) was also significantly higher than that after 3 doses of 40 μg (77%) (P = 0.004). Multivariable analysis showed that none of the variables contributed to seroconversion.
Conclusions: We found that 4 doses of 40 μg did not lead to significantly more seroconversion than 3 doses of 20 μg.


Implication for health policy/practice/research/medical education:
This article presents Hepatitis B Vaccination in Patients with chronic renal disease.
Please cite this paper as:
Ahmadi F, Ramezani M, Razeghi E, Ranjbarnovin N, Khazaeipour Z. A randomized Controlled Trial of Two Schedules of Hepatitis B Vaccination in Predialysed Chronic Renal Failure Patients. Hepat Mon. 2012;12(5): 344-8. DOI: 10.5812/hepatmon.6438
NCT registration identifier:
NCT01468051

Copyright © 2012 Kowsar Corp. All rights reserved.


Keywords

Kidney Failure, Chronic Hepatitis B Vaccination

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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