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The Role of Aflatoxins in Hepatocellular Carcinoma

AUTHORS

Hui-Chen Wu 1 , Regina Santella 2 , *

AUTHORS INFORMATION

1 Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, rps1@columbia.edu, NY 10032, USA

2 Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, USA

How to Cite: Wu H, Santella R. The Role of Aflatoxins in Hepatocellular Carcinoma, Hepat Mon. 2012 ; 12(10):7238. doi: 10.5812/hepatmon.7238.

ARTICLE INFORMATION

Hepatitis Monthly: 12 (10); 7238
Published Online: October 11, 2012
Article Type: Review Article
Received: May 20, 2012
Accepted: July 11, 2012
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Abstract

Context: Hepatocellular carcinoma (HCC) is one of the most common cancers in the world but with a striking geographical variation in incidence; most of the burden is in developing countries. This geographic variation in HCC incidence might be due to geographic differences in the prevalence of various etiological factors.

Evidence Acquisition: Here, we review the epidemiological evidence linking dietary exposure to aflatoxin B1 (AFB1) and risk of HCC, possible interactions between AFB1 and hepatitis B virus (HBV) or polymorphisms of genes involved in AFB1-related metabolism as well as DNA repair.

Results: Ecological, case-control and cohort studies that used various measures of aflatoxin exposure including dietary questionnaires, food surveys and biomarkers are summarized.

Conclusions: Taken together, the data suggest that dietary exposure to aflatoxins is an important contributor to the high incidence of HCC in Asia and sub-Saharan Africa, where almost 82% of the cases occur.

Keywords

Aflatoxins Aflatoxin-albumin Adducts Hepatitis B Virus Hepatocellular Carcinoma

© 2012, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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