Alpha-1 Antitrypsin Deficiency PI*Z and PI*S Gene Frequency Distribution Using on Maps of the World by an Inverse Distance Weighting (IDW) Multivariate Interpolation Method

Ignacio Blanco; Frederick J. de Serres; Victoriano Crcaba; Beatrz Lara; Enrique Fernndez-Bustillo

doi:10.5812/hepatmon.7434

Alpha-1 Antitrypsin Deficiency PIZ and PIS Gene Frequency Distribution Using on Maps of the World by an Inverse Distance Weighting (IDW) Multivariate Interpolation Method

Ignacio Blanco ^{2
, *} , Frederick J. de Serres ³ , Victoriano Crcaba ⁴ , Beatrz Lara ⁵ and Enrique Fernndez-Bustillo ⁶

Authors Information

² Alpha1-Antitrypsin Deficiency Spanish Registry, ignablanco@yahoo.com, Spain

³ National Institute of Environmental Health Sciences, Research Triangle Park, USA

⁴ Department of Internal Medicine, Valle del Naln Hospital, Spain

⁵ Hospital Universitario Arnau de Vilanova, Avda, Institut de Recerca Biomdica de Lleida (IRB), CIBERES Instituto Salud Carlos III, Pneumology Service, Institut de Recerca Hospital Universitari Vall dHebron, Spain

⁶ Biostatistics Unit, Central University Hospital of Asturias, Spain

Article information

Hepatitis Monthly: October 21, 2012, 12 (10); 7434
Published Online: October 21, 2012
Article Type: Research Article
Received: July 9, 2012
Accepted: August 2, 2012
DOI: 10.5812/hepatmon.7434

To Cite: Blanco I, de Serres F, Crcaba V, Lara B, Fernndez-Bustillo E. et al. Alpha-1 Antitrypsin Deficiency PI*Z and PI*S Gene Frequency Distribution Using on Maps of the World by an Inverse Distance Weighting (IDW) Multivariate Interpolation Method, Hepat Mon. 2012 ; 12(10):7434. doi: 10.5812/hepatmon.7434.

Abstract

Materials and Methods: Available data provided by epidemiological studies performed in 94 of 193 countries worldwide was used to develop detailed maps of these two alleles, We employed an informatics mathematical approach, namely: the ArcMap [a component of ESRIs ArcGIS Geographical Information System (GIS), for Microsoft Windows], based on the inverse distance weighting (IDW) multivariate interpolation method, which creates new numerical points from known data, using a simple logarithm based in the distance existing between them

Conclusions: By using this approach, striking differences were found among regions, and unsuspected significant values of the PI*S and PI*Z alleles frequencies were obtained for several geographic regions where have not been studied yet. In fact, some of these regions might be considered as priority targets for further screening studies on AAT deficiency, in order to identify, and properly manage, individuals at risk for the diverse adverse health effects associated with AAT deficiency.

© 2012, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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Alpha-1 Antitrypsin Deficiency PIZ and PIS Gene Frequency Distribution Using on Maps of the World by an Inverse Distance Weighting (IDW) Multivariate Interpolation Method

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Hepatitis Monthly

Published by: Kowsar

Alpha-1 Antitrypsin Deficiency PI*Z and PI*S Gene Frequency Distribution Using on Maps of the World by an Inverse Distance Weighting (IDW) Multivariate Interpolation Method

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Alpha-1 Antitrypsin Deficiency PIZ and PIS Gene Frequency Distribution Using on Maps of the World by an Inverse Distance Weighting (IDW) Multivariate Interpolation Method