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High Serum Levels of TGF-? in Iranians With Chronic HBV Infection

AUTHORS

Hossein Khorramdelazad 1 , Gholamhossein Hassanshahi 1 , Behzad Nasiri Ahmadabadi 2 , Mohammad Kazemi Arababadi 2 , *

AUTHORS INFORMATION

1 Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran

2 Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran

How to Cite: Khorramdelazad H, Hassanshahi G, Nasiri Ahmadabadi B, Kazemi Arababadi M. High Serum Levels of TGF-? in Iranians With Chronic HBV Infection, Hepat Mon. 2012 ; 12(11):7581. doi: 10.5812/hepatmon.7581.

ARTICLE INFORMATION

Hepatitis Monthly: 12 (11); 7581
Published Online: November 4, 2012
Article Type: Brief Report
Received: August 2, 2012
Accepted: September 16, 2012
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Abstract

Background: The transforming growth factor-? (TGF-?) is an important cytokine with anti-inflammatory properties.

Objectives: The main purpose of this study was to compare the serum levels of TGF-? in a group of chronic HBV infected (CHB) patients as well as healthy individuals from South-East of Iran.

Patients and Methods: Sixty patients with CHB as well as sixty healthy individuals were enrolled in the study. ELISA technique was applied to measure the serum levels of TGF-? in both groups.

Results: Our results revealed that the serum levels of TGF-? were significantly increased in CHB patients in compare to healthy controls.

Conclusions: According to this result, it may be concluded that high serum levels of TGF-? may be a mechanism by which immune response against HBV is suppressed.

Keywords

Hepatitis B, Chronic Transforming Growth Factor Beta

© 2012, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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