High Serum Levels of TGF-? in Iranians With Chronic HBV Infection
Hepatitis Monthly: October 31, 2012, 12 (11); 7581
November 4, 2012
Article Type: Brief Report
August 2, 2012
September 16, 2012
G, Nasiri Ahmadabadi
B, Kazemi Arababadi
M. High Serum Levels of TGF-? in Iranians With Chronic HBV Infection,
The transforming growth factor-? (TGF-?) is an important cytokine with anti-inflammatory properties.
The main purpose of this study was to compare the serum levels of TGF-? in a group of chronic HBV infected (CHB) patients as well as healthy individuals from South-East of Iran.
Patients and Methods:
Sixty patients with CHB as well as sixty healthy individuals were enrolled in the study. ELISA technique was applied to measure the serum levels of TGF-? in both groups.
Our results revealed that the serum levels of TGF-? were significantly increased in CHB patients in compare to healthy controls.
According to this result, it may be concluded that high serum levels of TGF-? may be a mechanism by which immune response against HBV is suppressed.
Hepatitis B, Chronic; Transforming Growth Factor Beta
© 2012, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.