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Genotyping and Infection Rate of GBV-C among Iranian HCV- Infected Patients

AUTHORS

Reza Ghanbari 1 , Mehrdad Ravanshad 2 , * , Seyed Younes Hosseini 1 , Ramin Yaghobi 3 , Kiana Shahzamani 1

AUTHORS INFORMATION

1 Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IR.Iran

2 Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, ravanshad@modares.ac.ir, Tehran, IR.Iran

3 Department of Virology, Shiraz Transplant Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Fars, IR.Iran

How to Cite: Ghanbari R, Ravanshad M, Hosseini S, Yaghobi R, Shahzamani K. Genotyping and Infection Rate of GBV-C among Iranian HCV- Infected Patients, Hepat Mon. Online ahead of Print ; 10(2):80-87.

ARTICLE INFORMATION

Hepatitis Monthly: 10 (2); 80-87
Article Type: Research Article
Received: July 2, 2009
Accepted: February 18, 2010

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Abstract

Background and Aims: Hepatitis G virus/GB virus-C (HGV/GBV-C) is a newly identified member of the Flaviviridae family. Its clinical significance in chronic hepatitis C infection remains controversial. There is a geographical difference in the distribution of GBV-C in the world. The frequency of GBV-C infection among hepatitis C virus (HCV) infected patients varies. The aim of the current study was to determine the prevalence and genotypes of GBV-C among Iranian patients infected with chronic HCV.

Methods: Infection with GBV-C was surveyed in 71 chronic confirmed hepatitis C infected patients. These samples were collected at the Digestive Disease Research Center (DDRC) of Shariati Hospital, Tehran, Iran from January to October 2007. The 5’-UTR region of GBV-C RNA was detected using a novel in-house touchdown nested reverse transcription polymerase chain reaction (RT-PCR), the products were sequenced and the results were aligned and phylogenically analyzed.

Results: Of the 71 HCV-infected patients, 31 (43.6%) were found positive for GBV-C RNA. Sequencing and phylogenic analysis showed that the samples were Genotype 2 of GBV-C.

Conclusions: It seems that there is a high rate of GBV-C infection among Iranian patients infected with chronic HCV. In comparison with the six reference genotypes, it was observed that all the samples were categorized in Genotype 2 of GBV-C, prevalent in North America, Africa and in European countries.

Keywords: GBV-C, HCV, Prevalence, Genotyping, Iranian, 5’-UTR

Keywords

GBV-C HCV Prevalence Genotyping Iranian 5-UTR

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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