IF: 1.578
Cite Score:
1.45
THOMSON REUTERS - SCOPUS

Intraperitoneal Transplantation of Hepatocytes Embedded in Thermoreversible Gelation Polymer (Mebiol Gel) in Acute Liver Failure Rat Model

AUTHORS

Nyamathulla Parveen 1 , Aleem Ahmed Khan 2 , * , Subramani Baskar 3 , Mohammad Aejaz Habeeb 1 , Ravindra Babu 1 , Samuel Abraham 3 , Hiroshi Yoshioka 4 , Yuichi Mori 4 , Habibullah Chittoor Mohammad 1

AUTHORS INFORMATION

1 Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, India

2 Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, aleem_a_khan@rediffmail.com, A.P., India

3 Nichi-In Centre for Regenerative Medicine, India

4 Advance Research Centre for Science and Engineering, Waseda University, Japan

How to Cite: Parveen N, Khan A, Baskar S, Habeeb M, Babu R, et al. Intraperitoneal Transplantation of Hepatocytes Embedded in Thermoreversible Gelation Polymer (Mebiol Gel) in Acute Liver Failure Rat Model, Hepat Mon. Online ahead of Print ; 8(4):275-280.

ARTICLE INFORMATION

Hepatitis Monthly: 8 (4); 275-280
Article Type: Research Article
Received: May 15, 2008
Accepted: September 18, 2008

Crossmark

CHEKING

READ FULL TEXT
Abstract

Orthotopic liver transplantation (OLT) is the only treatment that improves the survival rate in patients with acute liver failure (ALF). Hepatocytes are anchorage dependent and require a substratum for their long-term survival. Various substrata are being used to improve the function and survival of these hepatocytes, but cannot be used clinically as they are animal derived. This has been overcome by thermoreversible gelation polymer (TGP). In the present study, rat hepatocytes embedded in TGP, were transplanted intraperitoneally in acute liver failure rat model. Efficacy of the transplanted cells was studied by assessing biochemical parameters and histopathology at different time points. The ALF condition reverted to normal 15 days after cell transplantation. The transplanted animals survived 100%. Therefore this study suggests that the cells in TGP provide substratum to the transplanted cells for long term survival and could successfully provide liver support in severe ALF.

Keywords

Hepatocytes Acute Liver Failure Transplantation Thermoreversible Gelation Polymers Histopathology

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Full Text

Full text is available in PDF

COMMENTS

LEAVE A COMMENT HERE: