Immune Response to Standard Dose of Hepatitis B Vaccine in HIV Positive Clients of Kermanshah Behavioral Diseases Counseling Center

AUTHORS

A. Janbakhsh 1 , * , S. Vaziri 2 , B. Sayad 2 , M. Afsharian 2 , M. Rezaei 2 , H. Montazeripour 2

1 Assistant Professor of Infectious Disease, Kermanshah University of Medical Science, [email protected], Kermanshah, IR.Iran

2 Assistant Professor of Infectious Disease, Kermanshah University of Medical Science, Kermanshah, IR.Iran

How to Cite: Janbakhsh A, Vaziri S, Sayad B, Afsharian M, Rezaei M, et al. Immune Response to Standard Dose of Hepatitis B Vaccine in HIV Positive Clients of Kermanshah Behavioral Diseases Counseling Center, Hepat Mon. Online ahead of Print ; 6(2):71-74.

ARTICLE INFORMATION

Hepatitis Monthly: 6 (2); 71-74
Article Type: Research Article
Received: May 15, 2006
Accepted: May 30, 2006

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Abstract

Background and Aims: Coinfection eventuality of HIV and HBV infection and having common transmission ways has turned Hepatitis B into a major health concern among HIV positive cases. The increasing number of HIV infected patients and their relevant problems, especially opportunistic infections, demands for Hepatitis B vaccination. This study, therefore was conducted to evaluate the immune response against hepatitis B vaccine and related factors among HIV positive cases and probable approaches to improve its level.
Methods: In this cross -sectional study, 169 HIV positive cases who were Kermanshah's Behavioral Disease Counseling Center's clients, with negative HBsAg and HBcAb ,were vaccinated against hepatitis B virus with a 20µg of recombinant HBsAg at 0-1-6 month schedule in deltoid region. A month after the last shot, their HBsAg titer was measured. Titers higher than 10 Iu/ml were considered as a suitable immune response. Data included in this study were: age, gender, CD4 count, antiretroviral treatment history, hepatitis C coinfection and injecting drug abuse. Then these data were analyzed through X2 test.
Results: Among 169 under study cases, immune response was overally 52.7% and this rate was 51.9% for males and 66.7% for females (P=0.313). Immune response was 54.3%, 44.3%, 45.3% in CD4 count>500, 200-499, and <200/mm3 respectively (P=0.039). In cases with and without antiretroviral treatment the immune response was 81.8% and 50.6%, respectively (P=0.045%).
Conclusions: In this study the CD4 count and history of antiretroviral therapy correlation with immune response level was significant, but other factors like age, HCV co-infection, drug abusing, and gender were ineffective factors in immune response to HBV vaccine. Therefore, early vaccination among cases with higher CD4 count and cases under antiretroviral treatment seems necessary.

Keywords

HIV HCV Vaccination Kermanshah

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