Peginterferon Alfa-2a (Pegasys) and Ribavirin in the Treatment of Chronic Hepatitis C
Mohammad Reza Zali
1
, *
,
Hamid Mohaghegh Shalmani
2
,
Mohsen Norouzinia
2
,
Amir Hooshang MohammadAlizadeh
2
,
Azita Nowroozi
2
and
Negar Behrouz
2
1 Research Center for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences & Study Group of Interferon in Iran (SG.IFN.IR), zali@ams.ac.ir, Tehran, IR.Iran
2 Research Center for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran, IR.Iran
*
Research Center for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences & Study Group of Interferon in Iran (SG.IFN.IR), zali@ams.ac.ir, Tehran, IR.Iran. Email:
zali@ams.ac.ir
Hepatitis Monthly: ,
4 (7) ; 75-78 Article Type: Research Article
To Cite:
Zali
M, Shalmani
H, Norouzinia
M, MohammadAlizadeh
A, Nowroozi
A, et al. Peginterferon Alfa-2a (Pegasys) and Ribavirin in the Treatment of Chronic Hepatitis C,
Hepat Mon.
Online ahead of Print
;4(7):75-78.
Abstract
Background and Aim: Pegylation of interferon alfa-2a is a new modality for treatment of chronic hepatitis C. This clinical trial was conducted to evaluate the efficacy and safety of PEG IFN in combination with ribavirin in CHC patients.Methods: Fifty seven patients with HCV RNA in serum, persistently elevated ALT and chronic C hepatitis on liver biopsy enrolled to this study. The patients received PEG IFN 180 micg per week plus ribavirin 10-15 mg/kg per day.Results: HCV RNA was negative in 37 patients (74%) after three months of beginning of study (EVR) and SVR occurred in 50% of all patients.Conclusion: Peginterferon alfa-2a plus ribavirin is safe and effective in treatment of naïve patients and relapsers.
Keywords:
Hepatitis C, Pegylated interferon alfa-2a, Ribavirin, Therapy
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