Adiponectin and Its Receptors in Chronic Hepatitis B Patients With Steatosis in China

Di Wu; Hongqi Li; Guoan Xiang; Liwei Zhang; Lihong Li; Yongmei Cao; Jinqian Zhang

doi:10.5812/hepatmon.6065

Adiponectin and Its Receptors in Chronic Hepatitis B Patients With Steatosis in China

Di Wu ¹ , Hongqi Li ⁸ , Guoan Xiang ³ , Liwei Zhang ⁴ , Lihong Li ⁵ , Yongmei Cao ^{6
, *} and Jinqian Zhang ^{7
, *}

Authors Information

¹ Department of Ultrasound, Air Force General Hospital of PLA, Beijing, China

⁸ Daping Hospital,Third Military Medical University, Chongqing, China

³ Department of General Surgery, the Second People's Hospital of Guangdong Province, Guangzhou, China

⁴ Department of Cardiology, the First Affiliated Hospital of Chinese PLA General Hospital, Beijing, China

⁵ Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xian, China

⁶ International Mongolian Hospital, Hohhot of Inner Mongolia, Hohhot, China

⁷ Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China

Corresponding Authors:

Article information

Hepatitis Monthly: April 18, 2013, 13 (4); 6065
Published Online: April 18, 2013
Article Type: Research Article
Received: May 22, 2012
Accepted: January 30, 2013
DOI: 10.5812/hepatmon.6065

To Cite: Wu D, Li H, Xiang G, Zhang L, Li L, et al. Adiponectin and Its Receptors in Chronic Hepatitis B Patients With Steatosis in China, Hepat Mon. 2013 ; 13(4):6065. doi: 10.5812/hepatmon.6065.

Abstract

Results: The two groups were found to be comparable with respect to demographic, biochemical, metabolic, histological, and viral characteristics. BMI, ?-GT, FPG, insulin, and insulin sensitivity estimated by the HOMA index were significantly higher in patients with steatosis. The viral load of HBV and HBeAg positivity was higher in patients with steatosis than those without steatosis. High serum adiponectin levels were significantly correlated with abnormal serum ALT level (vs. normal ALT, P = 0.000), and HBV genotype C (vs. genotype B, P = 0.018). In patients with chronic HBV, the insulin sensitizing adipokine adiponectin, and its receptor AdipoR2were associated with steatosis. While adiponectin may becorrelated with inflammation, adiponectin, and its receptors were not associated with viral factors.

Conclusions: Our results suggest that the role of adiponectin might be impaired in chronic hepatitis B with steatosis. Reduced hepatic expression of adiponectin and adipoR2 might be of pathophysiological relevance in CHB patients with steatosis. These findings indicated that reduced liver adiponectin expression may play an important role in the pathogenesis, and progression of CHB patients with steatosis. However, hepatic expression of adiponectin, and adipoR2 was not associated with various measures of HBV infection.

© 2013, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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Adiponectin and Its Receptors in Chronic Hepatitis B Patients With Steatosis in China

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Adiponectin and Its Receptors in Chronic Hepatitis B Patients With Steatosis in China

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