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Dual Role of miR-122 in Molecular Pathogenesis of Viral Hepatitis

AUTHORS

Hossein Sendi 1 , *

AUTHORS INFORMATION

1 1) The Liver-Biliary-Pancreatic Center, Cannon Research Center, Carolinas Medical Center. 2) Department of Biology, University of North Carolina at Charlotte, Shahin.Sendi@Carolinashealthcare.org, USA

How to Cite: Sendi H. Dual Role of miR-122 in Molecular Pathogenesis of Viral Hepatitis, Hepat Mon. Online ahead of Print ; 12(5):312-314. doi: 10.5812/hepatmon.6128.

ARTICLE INFORMATION

Hepatitis Monthly: 12 (5); 312-314
Article Type: Editorial
Received: February 6, 2012
Accepted: March 13, 2012
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Abstract

The hepatic microRNA (miRNA), miR-122, is the most abundant miRNA within the liver, where it accounts for 70% of the total miRNA pool. It is known that miR-122, as an unusual host factor, increases the abundance of hepatitis C virus (HCV) RNA in HCV infection by binding directly to the 5’-UTR of the viral genome. Therefore, it has been suggested as a potential target for the treatment of hepatitis C. However, recent evidence shows that miR-122 decreases HBV replication through the inhibitory effect of p53 on HBV transcription, and consequently it acts as a tumor-suppressor through both a decrease in HBV replication and by directly targeting cyclin G1, as well as Wnt/beta-catenin, and NDRG3 pathways. This paper will brie?y discuss the underlying mechanisms for the dual role of miR-122 in viral hepatitis, and explains why therapeutic applications of miR-122 may differ based on the underlying disease.


Implication for health policy/practice/research/medical education:
Mir-122 has been suggested as a candidate target for treatment of hepatitis C. This editorial briefly discusses the underlying mechanisms for the dual role of miR-122 in viral hepatitis, and explains why therapeutic applications of miR-122 may differ based on the underlying disease.
Please cite this paper as:
Sendi H. Dual Role of miR-122 in Molecular Pathogenesis of Viral Hepatitis. Hepat Mon. 2012;12(5): 312-4. DOI: 10.5812/hepatmon.6128

 Copyright © 2012 Kowsar Corp. All rights reserved


Keywords

Micro RNAs Hepatocyte Nuclear Factors Cyclin G1

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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