Serum Levels of IL-10 and IL-17A in Occult HBV-Infected South-East Iranian Patients

AUTHORS

Mohammad Kazemi Arababadi 1 , * , Ali Akbar Pourfathollah 2 , Abdollah Jafarzadeh 3 , Gholamhossein Hassanshahi 3

1 Department of Microbiology and Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences, kazemim@modares.ac.ir, Kerman, IR.Iran

2 Department of Immunology, School of Medical Sciences, Tarbiat Modares University, Tehran, IR.Iran

3 Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Kerman, IR.Iran

How to Cite: Arababadi M, Pourfathollah A, Jafarzadeh A, Hassanshahi G. Serum Levels of IL-10 and IL-17A in Occult HBV-Infected South-East Iranian Patients, Hepat Mon. Online ahead of Print ; 10(1):31-35.

ARTICLE INFORMATION

Hepatitis Monthly: 10 (1); 31-35
Article Type: Research Article
Received: November 13, 2009
Accepted: December 24, 2009

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Abstract

Background and Aims:  Occult hepatitis B infected (OBI) patients can not completely eradicate hepatitis B virus-DNA (HBV-DNA) from their liver and peripheral blood. The main aim of this study was to investigate the Interleukin (IL)-10 and IL-17A serum levels in patients suffering from OBI.

Methods: In this observational study, plasma samples of 3700 blood donors were tested for hepatitis B surface antigen (HBsAg) and antibodies to the hepatitis B core antigen (anti-HBc), using enzyme-linked immunosorbent assay (ELISA). The HBsAg-/anti-HBc+ samples were selected and screened for HBV-DNA, using the polymerase chain reaction (PCR). HBV-DNA positive samples were assigned as OBI cases and IL-10 and IL-17 serum levels were detected using ELISA.

Results: The results demonstrated that, 352 (9.5%) out of 3700 blood samples were HBsAg-/anti-HBc+ and HBV-DNA was detected in 57/352 (16.1%) of the HBsAg-/anti-HBc+ samples. Our results showed that the IL-10 and IL-17A serum levels increased significantly in the OBI cases in comparison to the controls (P < 0.001).

Conclusions: According to the results of this study the higher level of IL-10 production may suppress the functioning of the immune system against HBV in OBI patients. The elevated IL-17A serum level also indicates a long period of infection in the patients observed.

Keywords

Occult Hepatitis B Infection Interleukin-10 Interleukin-17 HBV-DNA

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