Hepatitis Monthly

Published by: Kowsar

Correlation Between miR-125b Expression and Liver Fibrosis in Patients with Chronic Hepatitis C

Camelia Sultana 1 , 2 , * , Adelina Rosca 1 , 2 and Simona Ruta 1 , 2
Authors Information
1 Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
2 Emergent Disease Department, Stefan S. Nicolau Institute of Virology, Bucharest, Romania
Article information
  • Hepatitis Monthly: 19 (1); e84615
  • Published Online: January 16, 2019
  • Article Type: Brief Report
  • Received: September 25, 2018
  • Revised: November 24, 2018
  • Accepted: December 11, 2018
  • DOI: 10.5812/hepatmon.84615

To Cite: Sultana C, Rosca A, Ruta S. Correlation Between miR-125b Expression and Liver Fibrosis in Patients with Chronic Hepatitis C, Hepat Mon. Online ahead of Print ; 19(1):e84615. doi: 10.5812/hepatmon.84615.

Copyright © 2019, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. European Union HCV Collaborators. Hepatitis C virus prevalence and level of intervention required to achieve the WHO targets for elimination in the European Union by 2030: A modelling study. Lancet Gastroenterol Hepatol. 2017;2(5):325-36. doi: 10.1016/S2468-1253(17)30045-6. [PubMed: 28397696].
  • 2. Motoyama H, Tamori A, Kubo S, Uchida-Kobayashi S, Takemura S, Tanaka S, et al. Stagnation of histopathological improvement is a predictor of hepatocellular carcinoma development after hepatitis C virus eradication. PLoS One. 2018;13(3). e0194163. doi: 10.1371/journal.pone.0194163. [PubMed: 29534101]. [PubMed Central: PMC5849339].
  • 3. Zhu Z, Zhang X, Wang G, Zheng H. Role of MicroRNAs in hepatocellular carcinoma. Hepat Mon. 2014;14(8). e18672. doi: 10.5812/hepatmon.18672. [PubMed: 25337143]. [PubMed Central: PMC4199151].
  • 4. Roberts AP, Lewis AP, Jopling CL. miR-122 activates hepatitis C virus translation by a specialized mechanism requiring particular RNA components. Nucleic Acids Res. 2011;39(17):7716-29. doi: 10.1093/nar/gkr426. [PubMed: 21653556]. [PubMed Central: PMC3177192].
  • 5. Kim JK, Noh JH, Jung KH, Eun JW, Bae HJ, Kim MG, et al. Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors miR-125a-5p and miR-125b. Hepatology. 2013;57(3):1055-67. doi: 10.1002/hep.26101. [PubMed: 23079745].
  • 6. Shrivastava S, Steele R, Ray R, Ray RB. MicroRNAs: Role in hepatitis C virus pathogenesis. Genes Dis. 2015;2(1):35-45. doi: 10.1016/j.gendis.2015.01.001. [PubMed: 25984557]. [PubMed Central: PMC4431773].
  • 7. Liu W, Hu J, Zhou K, Chen F, Wang Z, Liao B, et al. Serum exosomal miR-125b is a novel prognostic marker for hepatocellular carcinoma. Onco Targets Ther. 2017;10:3843-51. doi: 10.2147/OTT.S140062. [PubMed: 28814883]. [PubMed Central: PMC5546809].
  • 8. Akamatsu S, Hayes CN, Tsuge M, Miki D, Akiyama R, Abe H, et al. Differences in serum microRNA profiles in hepatitis B and C virus infection. J Infect. 2015;70(3):273-87. doi: 10.1016/j.jinf.2014.10.017. [PubMed: 25452043].
  • 9. Giray BG, Emekdas G, Tezcan S, Ulger M, Serin MS, Sezgin O, et al. Profiles of serum microRNAs; miR-125b-5p and miR223-3p serve as novel biomarkers for HBV-positive hepatocellular carcinoma. Mol Biol Rep. 2014;41(7):4513-9. doi: 10.1007/s11033-014-3322-3. [PubMed: 24595450].
  • 10. Castera L, Vergniol J, Foucher J, Le Bail B, Chanteloup E, Haaser M, et al. Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C. Gastroenterology. 2005;128(2):343-50. [PubMed: 15685546].
  • 11. Zaltron S, Spinetti A, Biasi L, Baiguera C, Castelli F. Chronic HCV infection: Epidemiological and clinical relevance. BMC Infect Dis. 2012;12 Suppl 2. S2. doi: 10.1186/1471-2334-12-S2-S2. [PubMed: 23173556]. [PubMed Central: PMC3495628].
  • 12. Hsi E, Huang CF, Dai CY, Juo SH, Chou WW, Huang JF, et al. Peripheral blood mononuclear cells microRNA predicts treatment outcome of hepatitis C virus genotype 1 infection. Antiviral Res. 2014;105:135-42. doi: 10.1016/j.antiviral.2014.03.003. [PubMed: 24637254].
  • 13. You K, Li SY, Gong J, Fang JH, Zhang C, Zhang M, et al. MicroRNA-125b promotes hepatic stellate cell activation and liver fibrosis by activating RhoA signaling. Mol Ther Nucleic Acids. 2018;12:57-66. doi: 10.1016/j.omtn.2018.04.016. [PubMed: 30195793]. [PubMed Central: PMC6023793].
  • 14. Nagpal V, Rai R, Place AT, Murphy SB, Verma SK, Ghosh AK, et al. MiR-125b is critical for fibroblast-to-myofibroblast transition and cardiac fibrosis. Circulation. 2016;133(3):291-301. doi: 10.1161/CIRCULATIONAHA.115.018174. [PubMed: 26585673]. [PubMed Central: PMC5446084].
  • 15. Bala S, Tilahun Y, Taha O, Alao H, Kodys K, Catalano D, et al. Increased microRNA-155 expression in the serum and peripheral monocytes in chronic HCV infection. J Transl Med. 2012;10:151. doi: 10.1186/1479-5876-10-151. [PubMed: 22846613]. [PubMed Central: PMC3477071].
  • 16. Fiorino S, Bacchi-Reggiani ML, Visani M, Acquaviva G, Fornelli A, Masetti M, et al. MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis B- and C-related-hepatocellular-carcinoma. World J Gastroenterol. 2016;22(15):3907-36. doi: 10.3748/wjg.v22.i15.3907. [PubMed: 27099435]. [PubMed Central: PMC4823242].
  • 17. Banzhaf-Strathmann J, Edbauer D. Good guy or bad guy: The opposing roles of microRNA 125b in cancer. Cell Commun Signal. 2014;12:30. doi: 10.1186/1478-811X-12-30. [PubMed: 24774301]. [PubMed Central: PMC4011766].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments