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Which Dose of Acetaminophen is Safe in Cirrhotic Patients?

Hassan Soleimanpour 1 , Zahra Parsian 2 , Kavous Shahsavari Nia 3 , Farzad Rahmani 3 and Seyed Moayed Alavian 4 , 5 , *
Authors Information
1 Emergency Medicine Research Team, Tabriz University of Medical Sciences, Tabriz, Iran
2 Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
3 Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4 Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran
5 Tehran Hepatitis Center, Tehran, Iran
Article information
  • Hepatitis Monthly: May 31, 2019, 19 (5); e84767
  • Published Online: May 28, 2019
  • Article Type: Letter
  • Received: September 29, 2018
  • Revised: May 10, 2019
  • Accepted: May 12, 2019
  • DOI: 10.5812/hepatmon.84767

To Cite: Soleimanpour H, Parsian Z , Shahsavari Nia K , Rahmani F , Alavian S M. Which Dose of Acetaminophen is Safe in Cirrhotic Patients?, Hepat Mon. 2019 ; 19(5):e84767. doi: 10.5812/hepatmon.84767.

Copyright © 2019, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
Footnotes
References
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  • 2. Soleimanpour M, Imani F, Safari S, Sanaie S, Soleimanpour H, Ameli H, et al. The role of non-steroidal anti-inflammatory drugs (NSAIDS) in the treatment of patients with hepatic disease: A review article. Anesth Pain Med. 2016;6(4). e37822. doi: 10.5812/aapm.37822. [PubMed: 27843779]. [PubMed Central: PMC5100664].
  • 3. Andreasen PB, Hutters L. Paracetamol (acetaminophen) clearance in patients with cirrhosis of the liver. Acta Med Scand Suppl. 1979;624:99-105. [PubMed: 284720].
  • 4. Hayward KL, Powell EE, Irvine KM, Martin JH. Can paracetamol (acetaminophen) be administered to patients with liver impairment? Br J Clin Pharmacol. 2016;81(2):210-22. doi: 10.1111/bcp.12802. [PubMed: 26460177]. [PubMed Central: PMC4833155].
  • 5. Riley TR, Smith JP. Preventive care in chronic liver disease. J Gen Intern Med. 1999;14(11):699-704. doi: 10.1046/j.1525-1497.1999.11188.x. [PubMed: 10571719]. [PubMed Central: PMC1496761].
  • 6. Lewis JH, Stine JG. Review article: Prescribing medications in patients with cirrhosis - a practical guide. Aliment Pharmacol Ther. 2013;37(12):1132-56. doi: 10.1111/apt.12324. [PubMed: 23638982].
  • 7. Lucena MI, Andrade RJ, Tognoni G, Hidalgo R, Sanchez de la Cuesta F; Spanish Collaborative Study Group on Therapeutic Management of Liver Diseases. Drug use for non-hepatic associated conditions in patients with liver cirrhosis. Eur J Clin Pharmacol. 2003;59(1):71-6. doi: 10.1007/s00228-003-0586-2. [PubMed: 12684727].
  • 8. Hirschfield GM, Kumagi T, Heathcote EJ. Preventative hepatology: Minimising symptoms and optimising care. Liver Int. 2008;28(7):922-34. doi: 10.1111/j.1478-3231.2008.01816.x. [PubMed: 18783540].
  • 9. Benson GD. Acetaminophen in chronic liver disease. Clin Pharmacol Ther. 1983;33(1):95-101. doi: 10.1038/clpt.1983.14. [PubMed: 6848304].

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