Hepatitis Monthly

Published by: Neoscriber Demo Publisher
Crossmark

Fructose Consumption is Associated with Non-Alcoholic Fatty Liver Disease Risk: A Case-Control Study from Iran

Mina Darand 1 , Zahra Darabi 1 , Zahra Yari 1 and Azita Hekmatdoost 1 , *
Authors Information
1 Department of Clinical Nutrition, Faculty of Nutrition, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Article information
  • Hepatitis Monthly: 19 (4); e88283
  • Published Online: May 1, 2019
  • Article Type: Research Article
  • Received: December 25, 2018
  • Revised: March 7, 2019
  • Accepted: April 15, 2019
  • DOI: 10.5812/hepatmon.88283

To Cite: Darand M, Darabi Z, Yari Z, Hekmatdoost A. Fructose Consumption is Associated with Non-Alcoholic Fatty Liver Disease Risk: A Case-Control Study from Iran, Hepat Mon. Online ahead of Print ; 19(4):e88283. doi: 10.5812/hepatmon.88283.

Abstract
Copyright © 2019, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Rinella ME. Nonalcoholic fatty liver disease: A systematic review. JAMA. 2015;313(22):2263-73. doi: 10.1001/jama.2015.5370. [PubMed: 26057287].
  • 2. Bellentani S, Scaglioni F, Marino M, Bedogni G. Epidemiology of non-alcoholic fatty liver disease. Dig Dis. 2010;28(1):155-61. doi: 10.1159/000282080. [PubMed: 20460905].
  • 3. Younossi Z, Anstee QM, Marietti M, Hardy T, Henry L, Eslam M, et al. Global burden of NAFLD and NASH: Trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol. 2018;15(1):11-20. doi: 10.1038/nrgastro.2017.109. [PubMed: 28930295].
  • 4. Younossi ZM, Henry L. Economic and quality-of-life implications of non-alcoholic fatty liver disease. Pharmacoeconomics. 2015;33(12):1245-53. doi: 10.1007/s40273-015-0316-5. [PubMed: 26233836].
  • 5. Ghaemi A, Taleban FA, Hekmatdoost A, Rafiei A, Hosseini V, Amiri Z, et al. How much weight loss is effective on nonalcoholic fatty liver disease? Hepat Mon. 2013;13(12). e15227. doi: 10.5812/hepatmon.15227. [PubMed: 24358045]. [PubMed Central: PMC3867211].
  • 6. Lim JS, Mietus-Snyder M, Valente A, Schwarz JM, Lustig RH. The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome. Nat Rev Gastroenterol Hepatol. 2010;7(5):251-64. doi: 10.1038/nrgastro.2010.41. [PubMed: 20368739].
  • 7. Eslamparast T, Poustchi H, Zamani F, Sharafkhah M, Malekzadeh R, Hekmatdoost A. Synbiotic supplementation in nonalcoholic fatty liver disease: A randomized, double-blind, placebo-controlled pilot study. Am J Clin Nutr. 2014;99(3):535-42. doi: 10.3945/ajcn.113.068890. [PubMed: 24401715].
  • 8. Rahimlou M, Yari Z, Hekmatdoost A, Alavian SM, Keshavarz SA. Ginger supplementation in nonalcoholic fatty liver disease: A randomized, double-blind, placebo-controlled pilot study. Hepat Mon. 2016;16(1). e34897. doi: 10.5812/hepatmon.34897. [PubMed: 27110262]. [PubMed Central: PMC4834197].
  • 9. Yari Z, Rahimlou M, Eslamparast T, Ebrahimi-Daryani N, Poustchi H, Hekmatdoost A. Flaxseed supplementation in non-alcoholic fatty liver disease: A pilot randomized, open labeled, controlled study. Int J Food Sci Nutr. 2016;67(4):461-9. doi: 10.3109/09637486.2016.1161011. [PubMed: 26983396].
  • 10. Schwarz JM, Noworolski SM, Wen MJ, Dyachenko A, Prior JL, Weinberg ME, et al. Effect of a high-fructose weight-maintaining diet on lipogenesis and liver fat. J Clin Endocrinol Metab. 2015;100(6):2434-42. doi: 10.1210/jc.2014-3678. [PubMed: 25825943]. [PubMed Central: PMC4454806].
  • 11. Zhang DM, Jiao RQ, Kong LD. High dietary fructose: Direct or indirect dangerous factors disturbing tissue and organ functions. Nutrients. 2017;9(4). doi: 10.3390/nu9040335. [PubMed: 28353649]. [PubMed Central: PMC5409674].
  • 12. Jegatheesan P, De Bandt JP. Fructose and NAFLD: The multifaceted aspects of fructose metabolism. Nutrients. 2017;9(3). doi: 10.3390/nu9030230. [PubMed: 28273805]. [PubMed Central: PMC5372893].
  • 13. Chiu S, Sievenpiper JL, de Souza RJ, Cozma AI, Mirrahimi A, Carleton AJ, et al. Effect of fructose on markers of non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis of controlled feeding trials. Eur J Clin Nutr. 2014;68(4):416-23. doi: 10.1038/ejcn.2014.8. [PubMed: 24569542]. [PubMed Central: PMC3975811].
  • 14. Alwahsh SM, Gebhardt R. Dietary fructose as a risk factor for non-alcoholic fatty liver disease (NAFLD). Arch Toxicol. 2017;91(4):1545-63. doi: 10.1007/s00204-016-1892-7. [PubMed: 27995280].
  • 15. Ouyang X, Cirillo P, Sautin Y, McCall S, Bruchette JL, Diehl AM, et al. Fructose consumption as a risk factor for non-alcoholic fatty liver disease. J Hepatol. 2008;48(6):993-9. doi: 10.1016/j.jhep.2008.02.011. [PubMed: 18395287]. [PubMed Central: PMC2423467].
  • 16. Hekmatdoost A, Shamsipour A, Meibodi M, Gheibizadeh N, Eslamparast T, Poustchi H. Adherence to the dietary approaches to stop hypertension (DASH) and risk of nonalcoholic fatty liver disease. Int J Food Sci Nutr. 2016;67(8):1024-9. doi: 10.1080/09637486.2016.1210101. [PubMed: 27436528].
  • 17. Mokhtari Z, Poustchi H, Eslamparast T, Hekmatdoost A. Egg consumption and risk of non-alcoholic fatty liver disease. World J Hepatol. 2017;9(10):503-9. doi: 10.4254/wjh.v9.i10.503. [PubMed: 28443155]. [PubMed Central: PMC5387362].
  • 18. FAO . Dietary assessment: A resource guide to method selection and application in low resource settings. Rome: Food and Agriculture Organization of the United Nations; 2018.
  • 19. Esfahani FH, Asghari G, Mirmiran P, Azizi F. Reproducibility and relative validity of food group intake in a food frequency questionnaire developed for the Tehran Lipid and Glucose Study. J Epidemiol. 2010;20(2):150-8. doi: 10.2188/jea.JE20090083. [PubMed: 20154450]. [PubMed Central: PMC3900814].
  • 20. Mirmiran P, Esfahani FH, Mehrabi Y, Hedayati M, Azizi F. Reliability and relative validity of an FFQ for nutrients in the Tehran lipid and glucose study. Public Health Nutr. 2010;13(5):654-62. doi: 10.1017/S1368980009991698. [PubMed: 19807937].
  • 21. Food and Nutrition Information Center. Composition of foods raw, processed, prepared USDA national nutrient database for standard reference, release 27 documentation and user guide. Beltsville, Maryland: US Department of Agriculture: Food composition table (FCT); 2009.
  • 22. Jensen T, Abdelmalek MF, Sullivan S, Nadeau KJ, Green M, Roncal C, et al. Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. J Hepatol. 2018;68(5):1063-75. doi: 10.1016/j.jhep.2018.01.019. [PubMed: 29408694]. [PubMed Central: PMC5893377].
  • 23. Basaranoglu M, Basaranoglu G, Bugianesi E. Carbohydrate intake and nonalcoholic fatty liver disease: fructose as a weapon of mass destruction. Hepatobiliary Surg Nutr. 2015;4(2):109-16. doi: 10.3978/j.issn.2304-3881.2014.11.05. [PubMed: 26005677]. [PubMed Central: PMC4405421].
  • 24. Abdelmalek MF, Suzuki A, Guy C, Unalp-Arida A, Colvin R, Johnson RJ, et al. Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease. Hepatology. 2010;51(6):1961-71. doi: 10.1002/hep.23535. [PubMed: 20301112]. [PubMed Central: PMC2922495].
  • 25. Nier A, Brandt A, Conzelmann IB, Ozel Y, Bergheim I. Non-alcoholic fatty liver disease in overweight children: Role of fructose intake and dietary pattern. Nutrients. 2018;10(9). doi: 10.3390/nu10091329. [PubMed: 30235828]. [PubMed Central: PMC6165138].
  • 26. Jin R, Welsh JA, Le NA, Holzberg J, Sharma P, Martin DR, et al. Dietary fructose reduction improves markers of cardiovascular disease risk in Hispanic-American adolescents with NAFLD. Nutrients. 2014;6(8):3187-201. doi: 10.3390/nu6083187. [PubMed: 25111123]. [PubMed Central: PMC4145302].
  • 27. Kanerva N, Sandboge S, Kaartinen NE, Mannisto S, Eriksson JG. Higher fructose intake is inversely associated with risk of nonalcoholic fatty liver disease in older Finnish adults. Am J Clin Nutr. 2014;100(4):1133-8. doi: 10.3945/ajcn.114.086074. [PubMed: 25099548].
  • 28. Saadati S, Hekmatdoost A, Hatami B, Mansour A, Zahra Z, Hedayati M, et al. Comparing different non-invasive methods in assessment of the effects of curcumin on hepatic fibrosis in patients with non-alcoholic fatty liver disease. Gastroenterol Hepatol Bed Bench. 2018;11(Suppl 1):S8-S13. [PubMed: 30774801]. [PubMed Central: PMC6347983].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments