Genotype A2/adw2 Strain of Hepatitis B Virus in Turkey


Murat Sayan 1 , * , Sila Cetin Akhan 2 , Mithat Bozdayi 3

1 Clinical Laboratory, PCR Unit, University of Kocaeli, Faculty of Medicine, [email protected], Turkey

2 Department of Clinical Bacteriology and Infectious Diseases, University of Kocaeli, Faculty of Medicine, Turkey

3 Gastroenterology Department, Faculty of Medicine, University of Ankara, Turkey

How to Cite: Sayan M, Akhan S, Bozdayi M. Genotype A2/adw2 Strain of Hepatitis B Virus in Turkey, Hepat Mon. Online ahead of Print ; 10(4):302-305.


Hepatitis Monthly: 10 (4); 302-305
Article Type: Case Report
Received: January 12, 2010
Accepted: August 27, 2010




Background and Aims: Previous studies have demonstrated the dominance of genotype D subtype ayw in patients with hepatitis B virus infection in Turkey. The aim of the present study is to report, for the first time, genotype A2 subtype adw2 of hepatitis B virus in a patient who is an inactive hepatitis B carrier in Turkey.
Materials and Methods: Hepatitis B virus DNA isolated from the serum sample was amplified by polymerase chain reaction. The polymerase gene segment of the hepatitis B virus was directly sequenced. A distance matrix/UPGMA comparison was used for phylogenetic analysis, and the genotype of the virus was identified accordingly. The subgenotype and subtype of hepatitis B virus were also detected.
Results: The genotyping of the patient revealed that the isolated hepatitis B virus was genotype A2/adw2.
Discussion: The subtype is inconsistent with the previous data from Turkey; specifically, the identification of the A2/adw2
subtype of the hepatitis B virus in an inactive carrier is the first such case in Turkey. This finding suggests that the transmission of another genotype besides genotype D subtype ayw of the hepatitis B virus is possible in Turkey.


Hepatitis B virus Genotype

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