Immunology of HCV and HBV in Renal Failure and Transplantation

AUTHORS

Ali Karami 1 , * , Ali Najafi 2 , Seyed Moayed Alavian 2 , Mohammad Yaser Kiarudi 3

1 Research Center of Molecular Biology, Baqiyatallah University of Medical Sciences, [email protected], IR-Iran

2 Research Center of Molecular Biology, Baqiyatallah University of Medical Sciences, IR-Iran

3 Medical Sciences/University of Tehran, IR-Iran

How to Cite: Karami A, Najafi A, Alavian S, Kiarudi M. Immunology of HCV and HBV in Renal Failure and Transplantation, Hepat Mon. Online ahead of Print ; 7(2):93-101.

ARTICLE INFORMATION

Hepatitis Monthly: 7 (2); 93-101
Article Type: Review Article
Received: May 28, 2007
Accepted: August 18, 2007

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Abstract

Viral hepatitis has a special relationship to renal diseases. Hepatitis B and C viruses (HBV and HCV) infections are more prevalent in renal failure patients than in general population, an important cause of morbidity and mortality of renal failure patients on chronic dialysis and after renal transplantation. The association is largely due to the frequent use of blood products in patients with end-stage kidney diseases and multiple invasive medical procedures to which these patients are exposed. The effects of renal failure on the general health and immune status of patients with renal diseases also make viral hepatitis more difficult to diagnose as well as to manage. Finally, there have been few studies of the natural history and therapy of viral hepatitis in renal failure patients, making conclusions difficult. This paper will review the prevalence, incidence, clinical features, and natural histories of HBV and HCV infections and suggest recommendations for management and therapy in renal failure patients and patients undergoing renal transplantation.

Keywords

HBV HCV Renal Failure Renal Transplantation Immunology

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