Evaluation of HGV Viremia Prevalence and Its Co-Infection with HBV, HCV, HIV and HTLV-1 in Hemophilic Patients of Southern Khorassan, Iran

AUTHORS

Masood Ziaee 1 , * , Asghar Zarban 2 , Peyman Malekinejad 3 , Hadi Akhbary 4

1 Infectious Diseases, Birjand University of Medical Sciences, Birjand, Iran

2 Clinical Biochemistry, Birjand University of Medical Sciences, Birjand, Iran

3 General Practitioner, Birjand University of Medical Sciences, Birjand, Iran

4 Rheumatology, Birjand University of Medical Sciences, Birjand, Iran

How to Cite: Ziaee M, Zarban A, Malekinejad P, Akhbary H. Evaluation of HGV Viremia Prevalence and Its Co-Infection with HBV, HCV, HIV and HTLV-1 in Hemophilic Patients of Southern Khorassan, Iran, Hepat Mon. 2007 ; 7(1):11-14.

ARTICLE INFORMATION

Hepatitis Monthly: 7 (1); 11-14
Published Online: February 01, 2007
Article Type: Research Article
Received: February 15, 2006
Revised: April 01, 2006
Accepted: October 02, 2006

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Abstract

Background and Aims: The GB virus-C (GBV-C) and Hepatitis G virus (HGV), collectively known as GBV-C/HGV and
transmitted through blood transfusion and blood components. A co-infection of HGV and HCV is often seen in patients
with hemophilia. The paucity of information about rate of GBV-C infection among hemophilic patients in Iran promoted
the current study.
Methods: This study was performed on 80 hemophilic patients from south Khorassan branch of Iranian hemophilia
society in Birjand. All 80 serum samples were tested for hepatitis B surface antigen (HBs-Ag), Anti HCV, Anti HIV, and
Anti HTLV-1. All sera positive for HCVAb were retested by recombinant immunoblot assay as a complementary test. Also,
Serum HCV-RNA, HCV genotyping and HGV-RNA were detected.
Results: The prevalence of HGV-RNA was 5% (4 of 80). The prevalence of Anti HCV positive was 26.3% (21 of 80) and
HCV- RNA was detected in 80% (17 of 21) of these patients. Co infection of HGV with HCV was 5%. HBsAg and Anti
HIV were negative in all of our patients. Anti HTLV-1 was detected in one patient (1.25%).
Conclusions: HGV and HCV are prevalent in South Khorassan hemophilic patients. Prevalence of HGV infection is less
than HCV but it is more prevalent than HBV, HIV and HTLV-1 infection.

Keywords

GBV-C Hemophilia Hepatitis G Hepatitis C

© 2007, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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